Serum Hope for MS

Copyright 2004 Times Newspapers Limited
The Times (London)

July 5, 2004, Monday

Serum Hope for MS

Eve-Ann Prentice


EARLIER THIS year, Michael Bovingdon had become too ill to play ball
with his three-year-old son; his limbs were stiffening, he was plagued
by fatigue and the worsening of his symptoms was beginning to depress

However now, to his amazement, the 41-year-old farmer from Windsor is
able to throw and catch a ball, even to play rounders, and has been
able to stay up later than his usual 9pm bedtime.

He is one of hundreds of multiple sclerosis (MS) sufferers who this
year began regular injections of a new drug based on goat serum. Many
of them have reported startling improvements in their condition. While
the drug's manufacturers are reluctant to make any claims until
clinical trials are complete, anecdotal evidence suggests that it not
only eases symptoms, but may reverse damage wreaked by the disease.

Dozens of examples of huge improvements have been reported by patients
and doctors. Among those claiming near-miraculous results is Alan
Osmond, of the 1970s pop group the Osmond Brothers, who travelled from
his home in the US to the UK to gain access to the serum.

The treatment has raised interest among those with MS and their

Thousands of sufferers not chosen to take part in the trials are
clamouring for a chance to take the drug. The only side-effect
reported has been occasional reddening of the skin at the injection
site, and even this appears to happen only in the initial stages of

This month the results of tests carried out on six patients at the
Wellington Hospital in North London have added to the excitement. In
the observational study, sight problems, common in MS sufferers, were
found to improve soon after treatment. As a study report says: "Within
an hour of the injection, there was significant improvement in colour
vision, and comparison of pre-treatment and follow-up data also showed
significant benefit."

The drug, Aimspro, manufactured by the UK-based Daval International,
is made from the purified serum (the liquid part of blood) taken from
specially vaccinated goats bred in America.

It is reported to work for up to 85 per cent of patients, says Judy
Graham, an MS sufferer who edits a specialist magazine, New Pathways,
for the MS Resource Centre. "This means that they improve, from
slightly to dramatically; it may also prevent or delay the progression
of the disease. No one knows why it works for some people more than

Alan Osmond, 55, had MS diagnosed years ago and suffered numbness on
his right side, sluggish eyesight and bladder and bowel problems.
After the first treatment he noticed a dramatic improvement. "Right
away I had more strength in my right side," he tells New Pathways.
"Before the treatment you could easily have pushed my hand down. But
after the treatment, you couldn't. Almost immediately I could walk
faster, better, quicker. And at dinner that night I could cut the
steak myself -something I haven't been able to do for around five
years. My bladder improved and my mind felt fresher."

Over the next 48 hours he continued to feel better. "I went with my
wife to a mall and was able to walk all the way round -before I had to
get round in one of those electric carts. Also, I used to wear a leg
brace because of foot drop and my knees used to buckle under me. Now I
don't need the leg brace."

Dr Bryan Youl, consultant neurophysiologist at the Royal Free and
National hospitals in London, is enthusiastic about the serum (he took
part in the eyesight tests at the Wellington). "It seems to turn a
switch and restore a level of conduction in damaged fibres," he says.
"The MS world is littered with failed promises, but this looks
promising indeed. Patients are showing signs of recovery in front of
your eyes. I must emphasise that only with controlled trials can we
say if it is of real long-term benefit."

Marion Thanisch, 43, who took part in the Wellington study, has been
taking the serum for about three months. "I noticed an immediate
effect -within three weeks my fatigue levels were improving and I no
longer have to hang on to things while moving around. I really think
they have cracked it with this drug."

Thanisch, an unmarried layout designer from Walton-on-Thames, Surrey,
adds: "My clarity of thought has improved and I can keep going through
the day without hitting what I call the drop-out zone in the

Dr Ian Brooman, meanwhile, a GP who has also been administering the
serum to a small number of patients on an "informed consent basis",
says: "It seems to have a very beneficial effect with no real

Not everyone sees a dramatic improvement. Although Judy Graham is
impressed by the many success stories she has uncovered, she cannot
see that the drug has made any difference to her symptoms, although is
less tired and can get more done in a day.

The MS Society says that it is awaiting the results of the trials,
which are not expected until next year, before giving its verdict. A
spokesman, David Harrison, says: "There are substantial anecdotal
reports of people receiving benefits."

Daval International, meanwhile, has made Aimspro available to 150
people through their doctors on an "informed consent" basis, and 40
people are taking part in the main trial into the drug at the Atkinson
Morley Wing of St George's Hospital Medical School in Tooting, South
London (the consultant in charge of the trial is Dr David Barnes, a
leading neurologist in the field of multiple sclerosis).

Back on his farm, Michael Bovingdon is euphoric. His wife, Melanie,
says that he has improved "in many ways. More than anything, his mood
has improved. He could be quite sour but now he is laughing again".
Submitted  7/6/2004 4:27:34 PM